Tuesday, December 31, 2019
A1 Cava - 2459 Words
Unit 301 Understanding the Principles and Practices of Assessment |1.1 Explain the roles functions of: | |initial assessment in identifying learner needs | |formative assessment in tracking learner progress | |summative assessment in assessing learner achievement | |The initial assessment pin-points the learners individual needs. This can lead to additional support beingâ⬠¦show more contentâ⬠¦It is positive, tending to stress what a learner can do rather than what they | |cannot. | |1.2 Explain the following key concepts and principles of assessment: | |assessment as a process of making judgments of learnersââ¬â¢ knowledge, skills and competence against set criteria | |what is meant by validity and reliability | |the role of evidence in making assessment decisions | |what is meant by evidence being authentic, sufficient and current | |the importance of objectivity and fairness to learners | |the importance of transparency for the learner | |There are many principles of assessment should be valid, Validity ensures that assessment tasks and associated criteria effectively | |measure leanerââ¬â¢sShow MoreRelatedSystemic Lupus Erythematosus ( Sle )1591 Words à |à 7 PagesSystemic Lupus Erythematosus Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple tissues and systems and with significant variable clinical features and organ involvement (Cava, 2010). It is characterized by a chronic, relapsing, inflammatory and often febrile multisystemic disorder of connective tissue with wide spectrum of involvement of skin, joints, kidneys and serosal membranes. The exact etiology is noknown, but it represents failure of the regulatory mechanisms
Monday, December 23, 2019
Native American And Native Americans - 1292 Words
In the United States, Native Americans are considered to be people whose pre-Columbian ancestors were indigenous to the lands within the nation s modern boundaries. These peoples were composed of numerous distinct tribes, bands, and ethnic groups, and many of these groups survive intact today as sovereign nations. The terms Native Americans use to refer to themselves vary regionally and generationally, with many older Native Americans self-identifying as Indians or American Indians, while younger Native Americans often identify as Indigenous. Which terms should be used to refer to Native Americans has at times been controversial. The term Native American has been adopted by major newspapers and some academic groups, but has not traditionally included Native Hawaiians or certain Alaskan Natives, such as Aleut, Yup ik, or Inuit peoples. Indigenous American peoples from Canada are known as First Nations. Since the end of the 15th century, the migration of Europeans to the Americas has led to centuries of exchange and adjustment between Old and New World societies. Most Native American groups had historically lived as hunter-gatherer societies and preserved their histories by oral traditions and artwork, which has resulted in the first written sources on the conflict being authored by Europeans. At the time of first contact, the indigenous cultures were quite different from those of the proto-industrial and mostly Christian immigrants. Some of the Northeastern andShow MoreRelatedNative American And Native Americans1137 Words à |à 5 PagesNative American Displacement Long ago on the great plains, the buffalo roamed and the Native Americans lived amongst each other. They were able to move freely across the lands until the white men came and concentrated them into certain areas. Today there are more than five-hundred different tribes with different beliefs and history. Native Americans still face problems about the horrific history they went through and today s discrimination. The removal of American Indian tribes is one of theRead MoreNative American And Native Americans1221 Words à |à 5 Pages1607, the Native Americans have been treated poorly by the Europeans. The settlers came and stripped the Natives of their land by wars that the Natives were not equipped to fight. Native Americans were forced to move towards the west into uncharted territory and many died on the journey. The American government later made many promises to the Native Americans that were unkept, which had a very troubling effect on their communities. The promises the Unite d States government made to the Native AmericansRead MoreNative American And Native Americans871 Words à |à 4 Pages Native Americans have been forced out of their culture over time, forced into assimilation, lost their rights, and have lost their land due to policies and laws by the whites that canââ¬â¢t bear the Native American way of life. There used to be many Native American tribes all throughout North America, and now these tribes are spread across the country and are blended into the rest of the population. The native ways have changed drastically in the last two centuries due to relocation programs, IndianRead MoreNative American And Native Americans1187 Words à |à 5 Pagesmany Native American had already been there and the government were building railroads and roads. People rushed to settle in the west to mine for gold. Cities and town along with railroad and roads building at a rapid pace changed the habits of the buffalo. Buffalo were an important symbol in the Native Americans live they used buffalo as their main food source and they use the skin to make clothes and teepee covering , bones for silverware and hunting tools like arrow. The Native Americans makeRead MoreNative American And The American Of Native Americans1451 Words à |à 6 PagesThe Native American population has suffered many tragedies at the hands of the United States government, from their first interactions through the mid-twentieth century. Government policies concerning American Indians worked in conjunction with the prejudices harbored by the majority of the white population in the United States to suppress Native American liberties and strip them of their cultural identity. These policies gave little to no regard for Native American customs, personal expression,Read MoreNative American And Native Americans950 Words à |à 4 Pages countries went through imperialism, reconstruction and wars to pursuit their freedom. Native Americanââ¬â¢s embarked on new discover ies in America, which began conflicts with White Americans wanting control over what Native American had. Native Americans believed in freedom for the nation, but things began to change for them, when White American passed the Indians removal act. African American and Native American had similar experiences to pursuit their freedom. Both races were treated like they didnââ¬â¢tRead MoreNative American And Native Americans1156 Words à |à 5 Pageswith the Native Americans. The whites had different ideas that they wanted to contribute to the country, and the Native Americans wanted to stay loyal to their cultural traditions. The early people of the United States gradually gained control of the country. This lead to Native Americans being methodically pushed off their land, deceived multiply through a broken treaty, and most of all, not being completely recognized as citizens by the rest of American society. Some of these Native American groupsRead MoreNative American And Native Am ericans2248 Words à |à 9 PagesThe Native Americans, their origin and similarities with Native Finns Native Americans, the first settlers of the Americas arrived to the continent about 15 000 years ago. Crossing a land bridge between Asia and America during the ice age. It was not just one group that spread across the continent, but small groups of migrants for a long time period. The land bridge which the migrants used to cross between the continents does not exist today, but is instead known as the Bering Strait. All of theRead MoreNative American And Native Americans1832 Words à |à 8 Pagessettlements and still maintain a sense of self and native cultural identity. Many of the hardships experienced by the Native American Indians were the results of empty promises made by European settlers who used foreign laws, religion, and language barriers to oppress those Indians who were willing to conform. Later, and further into the development of the United States, foreign laws and languages were used as a premise to manipulate the Native Americans into giving up their promised lands so big businessesRead MoreNative American And Native Americans2251 Words à |à 10 Pageshistorical evidence, the notion: ââ¬Å"Native ââ¬âAmericans were not the first inhabitant of America is a complete false. For centuries, history kept accurate and vivid account of the first set of people who domiciled the western hemisphere. Judging by that record and evidence, below are the first set of Native-American people who inhabited the western hemisphere, including the new ââ¬Å"Americaâ⬠before the arrival of another human raceâ⬠¦ The Iroquois: The Iroquois of Native Americans were one of the tribes that lived
Sunday, December 15, 2019
The financial statements in assessing a companyââ¬â¢s performance and prospects. Free Essays
Introduction Revenue is a key element to the users of the financial statements, in assessing a companyââ¬â¢s performance and prospects. However, revenue-recognition standards in U.S GAAP differ from those in IFRS, and both sets of requirements are considered to be in need of improvement. We will write a custom essay sample on The financial statements in assessing a companyââ¬â¢s performance and prospects. or any similar topic only for you Order Now In June 2002 the FASB and the IASB started a joint project to clarify those principles and to create common revenue-recognition standards that companies can apply across various industries and transactions. It aims to remove inconsistencies and weaknesses in existing revenue-recognition standards and practices and to provide a more robust framework for addressing revenue recognition issues. In this report we are going to analyze the main problems that are involved in the revenue-recognition, the views that have been taken into concern by the two boards and assess the appropriateness of the project and their thinking. Main Problems involved in revenue recognition: Problems arise in both US.GAAP and IFRS. As far as it concerns the US.GAAP, many standards exists that define an earnings process inconsistently. At this case the concept of an earning process might not be precisely defined and people often disagree on how it applies to particular situations. Take into consideration a cable television provider. Does its earnings process involve only the provision of a cable signal to the customer over the subscription period or is the service of connecting the customer to the cable network an additional earnings process? According to the Statement No. 52 of FASB,Financial Reporting by Cable Television Companies, ââ¬Ëan entity accounts for connection services as a separate earnings process and recognizes revenue for them when rendered (but only in an amount equal to direct costs).ââ¬â¢ The fact that entities apply the earning process differently to economically similar transactions makes the usefulness of the approach questionable. There are also some gaps in guidance and conflicts with asset and liability definitions. There is not for example a general standard on recognizing revenue for services. More guidance is needed because the earnings approach sometimes leads to misinterpretation of an entityââ¬â¢s contractual rights and responsibilities in financial statements. Such approach accounts for revenue with little consideration of how assets and liabilities arise and change over the life of a contract. As with the US.GAAP, revenue-recognition standards in IFRS could lead to misinterpretation of the financial statements since the recognized amounts might not represent the economic reality. This due to the fact that revenue-recognition of a sale, depends mostly on when the risks and rewards of ownership of the goods are transferred to a customer. This could lead a firm to recognize a good as inventory even after the customer has obtained control over it. This is inconsistent with the IASB definition of an asset which depends on the control of the good and not on the risk and the rewards of owning the good. IFRS also lack guidance in transactions that involve the delivery of more than one good or service,that is a multiple element arrangement. IAS 18 does not state clearly how or when a firm entity should segment a single transaction into components. Guidance is also needed on the measurement of the elements of such arrangements. As no particular measurement target exists, entities apply various approaches to comparable transactions, that lessens the comparability of revenues across entities. This comparability is also being reduced by the non-existence of a clear distinction between goods and services. There is also inconsistency between IAS 11 and IAS 18. Between those two there is not a clear and straightforward principle to apply in changing and complex transactions. The IAS 11 principle states that an economic entity should recognize revenue as the activities required to complete a contract that takes place. The IAS 18 on the contrary, states that revenue should be recognised only when an entity transfers control and the risks and the rewards of ownership of the goods to the customer. The views taken by the two boards Both IASB and FASB are pursuing an approach that focuses on changes in assets and liabilities rather than concept of realization and earned. The approach was chosen because the realization earned approach involves recognising late debits and overdue credits that do not meet the definitions of assets and liabilities. Through this approach revenue-recognition would result from changes in assets and liabilities rather than from satisfaction of the realization and earned criteria. The basic principle of the new proposed model is that an entity should recognise revenue when it transfers goods or services to a customer in the amount of consideration that the entity expects to receive from the customer. There have been suggested five key-proposals for this model. The first is concerned with identifying the contracts with the customer. A company could combine two or more contracts together if the prices of those contracts are interdependent. Equally, a company could account a single contract as two or more contracts if some goods or services are priced independently of other goods or services. The second is how to identify the separate performance obligations. A contract is all about promises to provide goods or services to a customer. Such promises are called ââ¬Å"performance obligationsâ⬠. An entity would account for a performance obligation separately only if the promised good or service is distinct. A good or service is distinct if it is sold separately or if it could be sold separately because it has a distinct function and profit margin. The third one is how to determine the transaction price. The transaction price is the amount of deliberation an entity expects to obtain from the customer in exchange for transferring goods or services. This price would reflect the companyââ¬â¢s probability weighted estimate of variable consideration in addition to the effects of the customerââ¬â¢s credit risk and the time value of money. The fourth one is how to allocate this price. A company would allocate the transaction price to all separate performance obligations in proportion to the standalone selling price of the good or service underlying each performance obligation. The last one is how to recognize revenue when a performance obligation is satisfied. An entity should recognize revenue when it satisfies a performance obligation by transferring the promised good or service to the customer, which is when the customer obtains control of the promised good or service. The amount of revenue recognized is the amount allocated to that performance obligation in the transaction price allocation step. Reasoned Critique Many entities criticized the proposed model, but we will take into account the views of ââ¬â¢Ã¢â¬â¢Big 4ââ¬â¢Ã¢â¬â¢. PriceWaterhouseCoopers agree with the boardââ¬â¢s objective to define certain principles for revenue recognition that would provide clearer and more consistent guidance. There are however some concepts of the proposed model that according to their opinion, are ambiguous. According to them, ââ¬â¢Ã¢â¬â¢the boards should consider a more practical approach in areas such as: (1)identification and separation of distinct performance obligations; (2)measurement and presentation of the impact of credit risk on revenue;(3)the impact of the time value of money on revenue recognition; and (4)accounting for warranties.ââ¬â¢Ã¢â¬â¢ The changes in those areas should benefit the adopting entities at a greater level in comparison with the incremental processes, systems and other costs that may occur. KPMG believes that itââ¬â¢s a critical that the new standard provide a framework capable of addressing the broad range of current and emerging revenue recognition issues. Despite the substantial changes in all areas, there are still some that lack revision or need further development. According to KPMG those areas are ââ¬Ëââ¬â¢the concept and indicators of transfer of control, identification of distinct performance obligations, determination of the transaction price for transactions with variable consideration, consideration of collectability in the determination of the transaction price, recognition of onerous performance obligations, and identification of constructive performance obligations.ââ¬â¢Ã¢â¬â¢ The boards should test the proposed model effectiveness to assess where itââ¬â¢s capable of being applied to various types of transactions. Ernst Young strongly believe that the five-step model will help entities to apply those principles. They are concerned however, about the application of the proposed model and the consequences of it. The organization notes: ââ¬Ëââ¬â¢A new standard on revenue will impact all entities and the consequences of some aspects of the model are only the beginning to become apparent. It needs to be given further consideration to the potential effects of the proposed model, including the subsequent accounting for transactions and that constituents need more time to consider the proposals and comment further on them.ââ¬â¢Ã¢â¬â¢ Finally Deloitte follows a more negative attitude towards the whole project. The organization disagrees with certain aspects of the Exposure Drafts proposals and they are more skeptical with the proposed model. The organization notes: ââ¬Ëââ¬â¢ Our main concern with the ED is that the material in relation to ââ¬Ëcontrolââ¬â¢ is neither well developed nor clearly explained-we believe that the EDââ¬â¢s proposals on how the transaction price should be allocated between performance obligations and on how to account for contract modifications that are judged interdependent, should be modified.ââ¬â¢Ã¢â¬â¢ The proposed model seems to be rather controversial. The clarity and the effectiveness of certain concepts seem to be questioned. A reasonable reaction, in my opinion, since many entities and accounting firms would be hesitant in the beginning. The same applies and for both IASB and FASB. A concept project of such scale as the revenue recognition joint-project, will have major difficulties in its conceptual framework. As long as, it stays in theory and is not tested under real circumstances, it will always have those who opposed to it. It needs to be field tested to ensure that is capable of being applied normally. There are many aspects that need to be revised and change. The Boards should take into account the results of the application of the proposed model and seek ways in which the adaption and transition would be smoother and better. Conclusion There are some serious implications in the revenue recognition process. For that reason, the two Boards proposed some views to help in eliminating those problems. Those views have been criticized by the world as for their strengths and weaknesses and the effectiveness of the proposed model has been questioned. Nonetheless, FASB-IASB joint revenue recognition project is a significant effort, which is crucial for the future accounting standards. As Sir David Tweedie, chairman of the IASB,said: ââ¬ËThe proposal by the two boards is the result of our intensified joint efforts. It is an important step towards a single global principle-based standard that would make it absolutely clear when revenue is recognized and why,ââ¬â¢Ã¢â¬â¢. How to cite The financial statements in assessing a companyââ¬â¢s performance and prospects., Essay examples
Saturday, December 7, 2019
Rosewood Hotels And Resorts free essay sample
Check with your professor for any additional instructions. o Include a cover page containing the title of the assignment, the studentââ¬â¢s name, the professorââ¬â¢s name, the course title, and the date. The cover page and the reference page are not included in the required assignment page length. The specific course learning outcomes associated with this assignment are: o Analyze the importance of customer life time value. o Evaluate the role of consumer behavior and perception in the marketing mix. Use technology and information resources to research issues in marketing in a global environment. o Write clearly and concisely about marketing in a global environment using proper writing mechanics. Grading for this assignment will be based on answer quality, logic/organization of the paper, and language and writing skills, using the following rubric Abstract Rosewood hotels Resorts, a privately held company was established in 1979 by Caroline Rose Hunt Trust Estate. In 1980, rosewood managed its first hotel, The Mansion on Turtle Creek, and old mansion in Dallas Texas. The Mansion was saved by Ms. Hunt, the daughter of H. L. Hunt, a Texas oil Tycoon. Rosewood, with the help of Hunt transformed the property into a world class hotel and restaurant. They ventured on to transform many existing properties to include Little Dix Bay, Virgin Islands, the newly built Lanesborough in London, and Las Al Paraiso in Mexico. This paper discusses the pros and cons of the Rosewood Hotels moving from individual brands to a corporate brand, discusses the general concept of CLTV and a wide variety of elements to differentiation, operational issues, and brand management. Additionally, this paper discusses how one assumption affects the results with an explanation that demonstrates an understanding of the concepts being applied Pros and Cons of Rosewood Hotels moving from individual brands to a corporate brand Rosewood hotels Resorts were so distinctive; each could thrive on its own name, without any corporate identification, in other words, the ââ¬Å"cookie cutter approachâ⬠. John Scott, Rosewoodââ¬â¢s newly appointed CEO and Robert Boulogne, vice president of sales and marketing considered a new brand strategy to boost the companyââ¬â¢s growth. Since Rosewood Hotels Resorts had minimal brand recognition with its guests, John Scott and Boulogne decided to unifying the hotels owned by the company are to promote the corporate Rosewood Brand prominently. To effectively show results of individual versus corporate branding strategies, Scott and Boulogne conducted a qualitative analysis considering pros and cons of each branding strategy, and a quantitative analysis to estimate the impact of Rosewoodââ¬â¢s corporate branding strategy on customer lifetime value (CLTV). From the research conducted by Rosewood, the most obvious and immediate pro to a corporate branding strategy is the projected increase in multi property stay guests from 5% to 10%. This has the potential to not only increase revenues but also brand awareness, recognition and word of mouth referrals. other advantages of Rosewood Hotels moving individual brands to corporate brand are increased brand wide usage, increased brand recognition, connection among properties, good positioning for competition, increased market/share, increase brand awareness, promotion of cross property usage, increased return visit, brand loyalty, increased revenue and building customer life values However, there are disadvantages of moving from individual brands to a corporate brand for Rosewood Hotels. This moment canned the ââ¬Å"cookie cutter approachâ⬠of doing business. Other disadvantages of having a corporate brand is ââ¬Å"no sense of placeâ⬠philosophy, loss of uniqueness, less differentiation, potential loss of brand equity, loss of discretion, guess and management resistance to change, increased marketing cost, competition tougher among corporate branded hotels, and change in the corporate culture is challenging. To ensure they were making the best decision to move corporate branding for Rosewood Hotels, Scott and Boulogne used the guest revenue and expense data to show the potential benefits, greater customer life value (CLTV) would outweigh the marketing a n operations cost connected with corporate branding. To accomplish this, Boulogne calculated and forecasted the CLVT for six years with and without a Rosewood brand to determine how the branding strategy would affect profit per quest. CLTV can be separated into three categories, aggregate metrics, program evaluation metrics, and customer-level targeting tools. Aggregate CLTV metrics is an ideal metric for identifying the profitability of customer segments and for tracking segment performance over time. Segments with high CLTV represent the most important customers. Segments with low or negative CLTV indicate that change is needed in the way the business markets to and services these customers (Koppock, 2002). Calculating the CLTV impact of a proposed marketing program is essentially the same as running a business case by calculating the ROI of the program. The important thing to remember is that positive incremental CLTV is the key criteria for program valuation. Avoid thinking, If these customers are worth $500 in CLTV, then I can certainly afford to spend $100 on retention. The purpose of marketing is to increase CLTV, not to spend, (Koppock, 2002). And Customer Level CLTV was previously mentioned for cable TV providers include several elements that represent customer-level actions (retention, upgrading, cross-purchasing, payment, servi ce calls). Building predictive models for each of these customer actions allows an individual level assignment of CLTV. This information can be used for differentiated marketing in several ways: Identify individual customers who are not profitable and change the customer relationship to improve profitability (reduce service levels, increase price, etc. ) or minimize the customer relationship (accept attrition, end proactive marketing). Customer Lifetime Value Calculator Rosewood hotels Resorts used a value calculator to show how the assumption affects the results of moving from the ââ¬Å"cookie cutter approachâ⬠to corporate branding Rosewood Case Analysis http://www. cribd. com/doc/64121596/MKT-Rosewood-Case-Analysis ROSEWOOD HOTELS AND RESORTS CASE Strategic issues and problems: The following report will describe and analyze the case of a private hotel management company called ââ¬Å"Rosewood Hotels and Resortsâ⬠. Rosewood hotels have 12 distinctive hotels worldwide with a strong brand image that makes each property unique. The dilemma found in this case is whether to keep the current i ndividual branding strategy or create a corporate branding strategy, without undercutting the distinctiveness of each hotel. To do so the following points will be covered: ( ( ( Recommendation on individual versus corporate branding strategies. Qualitative analysis considering pros and cons of each branding strategy Quantitative analysis estimating the impact of Rosewoodââ¬â¢s corporate branding strategy on customer lifetime value (CLTV) Recommendations: As we will observe in the qualitative analysis there are many disadvantages if the new strategy is implemented. However from an economic point of view we will see that implementing a new branding strategy is better for the company as the NPV per guest is higher (see quantitative analysis). Taking into account the Customer Lifetime Value Model Rosewood should implement a corporate branding strategy. However to minimize the disadvantages it would be essential to keep the name of some emblematic hotels such as ââ¬Å"Carlyleâ⬠in order for the clients to remain loyal. These hotels can add the name ââ¬Å"Rosewoodâ⬠, to keep its clients aware that they belong to this chain. I find it useful to separate the uses of CLTV into three categories: 1) aggregate metrics, 2) program evaluation metrics, and 3) customer-level targeting tools. Aggregate CLTV Metrics:à CLTV is an ideal metric for identifying the profitability of customer segments and for tracking segment performance over time. Segments with high CLTV represent the most important customers. Segments with low or negative CLTV indicate that change is needed in the way the business markets to and services these customers. CLTV for Program Evaluation:à Calculating the CLTV impact of a proposed marketing program is essentially the same as running a business case by calculating the ROI of the program. The important thing to remember is that positive incremental CLTV is the key criteria for program evaluation. Avoid thinking, If these customers are worth $500 in CLTV, then I can certainly afford to spend $100 on retention. The purpose of marketing is to increase CLTV, not to spend it. Customer Level CLTV:à The definition of CLTV previously mentioned for cable TV providers includes several elements that represent customer-level actions (retention, upgrading, cross-purchasing, payment, service calls). Building predictive models for each of these customer actions allows an individual level assignment of CLTV. This information can be used for differentiated marketing in several ways: Identify individual customers who are not profitable and change the customer relationship to improve profitability (reduce service levels, increase price, etc. ) or minimize the customer relationship (accept attrition, end proactive marketing). â⬠¢ Identify the drivers of CLTV and create programs that improve CLTV (marketing triggers, retention programs, etc. ). â⬠¢ Identify high value prospects by cloning the profitable customer base (find prospects with similar characteristics)
Friday, November 29, 2019
Searching for Self free essay sample
To find their identity one will search the depths of their character to find what lies within; often coming across a mirror image of the worldââ¬â¢s deception of how someone is ââ¬Å"expectedâ⬠to live their life. We as a people have been imprisoned by a definition of how to live our life. The great and sought after ââ¬Å"American Dreamâ⬠is followed by an almost perfectly blissful gratification for those ââ¬Å"luckyâ⬠enough to fall into the ways of the world; however, those who follow this illusion of righteousness discover that the dream of building their castle on sand will quickly collapse into a nightmare of materialistic rubble. Romans 12:2 calls mankind to conform no longer to the patterns of this world, but to be transformed by the renewing of your mind. Living life by Romansââ¬â¢ credence one will find their inner-self. Throughout life one may be pressured by the weight of the world to become one with the world; however, it is those who countervail t his expectancy that ripen into the great men of history. We will write a custom essay sample on Searching for Self or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page There is a juncture in life when one learns that living by the world expires the living, but to live separate from the world brings forth rejuvenation and joy in oneââ¬â¢s life. When one reaches this point of enlightenment, there is a realization of being an individual liberated from this world that becomes apparent, forcing the choice of staying worldly or becoming eccentric to the world by renouncing its ways. . So step up to a world of deception and reveal unto it the nature of integrity. It is at that beautiful moment of betrayal to the world that one will redefine their character and discover their true identity.
Monday, November 25, 2019
A Day Late and A Dollar Short â⬠Theology Essay
A Day Late and A Dollar Short ââ¬â Theology Essay Free Online Research Papers John came to me depressed and hopeless. As he talked, he painted a bleak picture of unemployment, old age, ill health, and feelings of failure and helplessness. Whatever I do and whatever I try, it always seems that Im a day late and a dollar short, said John dejectedly. Perhaps you can identify with John in some aspect of your life. One day Jesus met a man at the pool of Bethesda. It was a famous pool. Multitudes of sick and infirm people came to the pool seeking healing. It was believed by many that at certain seasons an angel would go down into the waters and stir the waters up. Whoever was first into the waters was healed of their disease. (See John 5:1-17). The man that Jesus encountered at the pool had been an invalid for thirty-eight years. When Jesus asked him if he wanted to be healed, he replied, more or less, Im always a day late and a dollar short. Actually the man said, Sir, I have no man to put me into the pool when the water is stirred up, but while I am coming, another steps down before me. (John 5:7). But that encounter with Jesus changed his life, brought healing, and hope. If you can identify with being a day late and a dollar short in some aspect of your life, come to the pool of Bethesda. Dont look for an angel, look to Jesus, who is. MERCIFUL. Even in the old covenant, before Jesus went to the cross, God displayed His mercy in various ways and occasions. During the Israelites trek through the wilderness, they began to murmur, complain, and rebel against God. God sent fiery serpents among them. Multitudes were bitten and died. When they cried out to God, He instructed Moses to make a brazen serpent and put it on a pole. If someone was bitten by a poisonous snake and looked on the brazen serpent, they were healed. David blessed such a merciful God with thanksgiving and praise. (See Psalm 103). Even before Jesus went to the cross to provide salvation and healing, God would send an angel down to trouble the water at the pool of Bethesda and bring healing to some. (See Isaiah 53; John 5:1-17). Why did He do it? Because He is merciful. Why did Jesus bother with this invalid who was always a day late and a dollar short? Because His compassions fail not. EXPECTATIONS. Jesus raises our expectations and hope. Jesus asked this invalid of thirty-eight years a very unusual question. Do you want to be well? One would think that would be a forgone conclusion. But Jesus knew that unless we raise our expectations, we will never be healed. We will be paralyzed by hopelessness, despair, fear, and doubt. This invalid was looking for someone to help him into the water. He had no one. But God wants us to raise our expectations from others, or even ourselves, and focus on Him. He is our expectation and hope. (See Jeremiah 29:11; Psalm 62:5; Luke 3:15; Romans 13:13). RAPHA is the Lord who heals (Jehovah-Rapha). When Moses led the Israelites through the wilderness, they had no water. They finally came to Marah, but could not drink the water because it was bitter. Moses cried out to the Lord and the Lord showed him a tree. Moses threw the tree into the water and the water became sweet. God made a covenant with Israel and revealed Himself as Jehovah Rapha the Lord your Healer. (See Exodus 15:22-26). I believe that tree, thrown into the water, is a type of the cross of Christ and Gods provision for us through the atonement of Christ. What do you need to be healed from? Is it sin? Bitterness? Sickness? Look to Rapha Jesus your Healer. COMMANDMENTS and obedience go together with healing, health, and hope. Jesus told the sick man at the pool to take up his bed and go home. The man was healed as he obeyed Jesus command. Read carefully Gods condition for healing in Exodus 15:26. Faith and obedience work together. YAHWEHS LORD. For years, this invalid had been looking to people to help him. God many times uses people, but only one Physician can heal our soul. Only Yahwehs Lord Jesus is the all-sufficient one. When the religious leaders asked who the man was who healed him, he didnt know. Later he met Jesus in the temple and discovered that Jesus is Yahweh (Jehovah). The name is derived from the Hebrew root to be, to become. It is the most sacred name for God. He is totally self-existent. Jesus said He is the One who has life in Himself. (John 5:26). Why do we look elsewhere? Why dont we rest in His unchangeableness? He has never failed. He cannot! The Lord (Yahweh) sent the man on his way with this admonishment. Behold, you have become well; do no sin anymore, so that nothing worse comes upon you. (John 5:14). Have you dealt with the sin issue in your life? Perhaps youve noticed that each points of this article forms an acrostic MERCY. If we confess our sins, He is faithful and just to forgive us our sins, and to cleanse us from all unrighteousness. (1 John 1:9). Research Papers on A Day Late and A Dollar Short - Theology Essay19 Century Society: A Deeply Divided EraThe Effects of Illegal ImmigrationThe Masque of the Red Death Room meaningsComparison: Letter from Birmingham and CritoCanaanite Influence on the Early Israelite ReligionArguments for Physician-Assisted Suicide (PAS)The Hockey GameThe Project Managment Office SystemMind TravelThe Fifth Horseman
Friday, November 22, 2019
Psychologists and Jury Selection Term Paper Example | Topics and Well Written Essays - 750 words
Psychologists and Jury Selection - Term Paper Example The researcher states that in case such as Bruno Hauptmann, there could be strong public mood against the accused which could influence the jury to convict the innocent. Here, the juristsââ¬â¢ personality characteristics and traits might play an important role. In a media intensity society, it is particularly true as it often wages psychological wars to mobilize public opinion over what it considers as truth. The trial of O. J. Simpson was characterized by ââ¬Ëcontinued media interest and public fascination with his actions and statements. The belief that ââ¬Å"he got away with murderâ⬠even led to proposals to reform and restrict the jury systemââ¬â¢. The certainty necessary to punish nay accused could be accumulated by the jurists based on their prejudices and worldview. Most importantly, according to Greene et.al, ââ¬Ëtruth is elusive, and in the legal system, all truth seekers are subject to human error, even though the system seems to assume that they approach infallibility. The failure to achieve perfection in our decision making will become evident as the steps in the trial process are reviewedââ¬â¢. Jury sentiments are directly a product of juristsââ¬â¢ opinions, attitudes and beliefs. Attorneys have two options for selecting new juries. First of all, a panel of prospective jurors need to be identified which is known as venire. Secondly, ââ¬Ëa process known as voir dire is employed to question and select the eventual jurorsââ¬â¢. It involves every jurist telling truth about himself/herself. This process naturally involves elimination as the jurists who hold biases over a particular case are dismissed from the trial. Only the ones who hold a free mind and free from limitations are selected. There is a difference between judgesââ¬â¢ decisions and Juriesââ¬â¢ decisions. It has been found that ââ¬Å"citizens believe a jury decision offers more procedural fairness (greater thoroughness, better representation of the commun ity, fewer personal biases affecting decisions) than a decision by a judgeâ⬠. Jury sentiments are the major cause for the discrepancies in the judicial verdicts. In their famous survey, ââ¬ËKalven and Zeisel, after reviewing the multitude of discrepancies, used this term to cover all trials in which, in the judgeââ¬â¢s view, the juryââ¬â¢s verdict was detrimentally determined by factors beyond the evidence and the lawââ¬â¢. Especially in victimless crimes, there could a stronger tendency for sentiments towards the culprit. In some cases, if the case gets more social importance through media intervention, the number of jurists may be relatively high. It is very difficult even to keep the jury selection procedure just as it would involve discrimination against minority religions, races, nationalities and other cognizable groups.
Wednesday, November 20, 2019
Week4Journal PHI445 Personal & Organizational Ethics Assignment
Week4Journal PHI445 Personal & Organizational Ethics - Assignment Example 1). Customers value affordability and are willing to shift to cheaper options while competitors discount their products. This occurs amidst high production costs. Competitiveness of the fast food industry, cost of production, and scarcity of resources among consumers are the reasons for the pressure and identifies competitors, consumers, and production resources as the responsible factors to the problem that strains McDonaldsââ¬â¢ profit margin. Reducing production costs through retrenching some workers and increasing workload of remaining workers, developing a brand image that will attract and retain customers are some of the possible solutions to the problem. Brand imaging is the better solution because of its focus on the market and its high probability of success through marketing initiatives. in addition and contrary to reducing number of employees and increasing their workload that promises harm to the society, brand imaging promises benefits to the company, its employees wh o will retain their jobs, and consumers who will derive greater utility. Marketing challenges and scepticism are however significant to brand image development (Wong, 2013). Change in taste and preferences challenge the companyââ¬â¢s objectives by reducing perceived value of its products and increasing competition from retailers that the changes favour. The changes may be pushed by customers needs or pulled by competitorsââ¬â¢ innovation and this identify responsibility of the two classes of stakeholders. The change leads to reduced demand and therefore lower profitability of the organization. Sensitivity to customersââ¬â¢ needs and market trends, and innovation into influencing customersââ¬â¢ taste are the possible solutions. Research based innovation is the suitable solution because of its wide scope and benevolence even though it faces the cost challenge (Wong, 2013). CARE International is an international nongovernmental organization that deals in
Monday, November 18, 2019
Effect Of Television On Family Relationships Essay
Effect Of Television On Family Relationships - Essay Example When the television was first introduced in the market, it was in the homes of the rich and were kept in bars, the latter being the place where it reached more people. Slowly there was a demographic shift in the TV viewing population. The middle-income and low-income people started to own or aspired to own a television set resulted in defining the nature of the programs shown. The program quality was not better than the high school dramaââ¬â¢s previously, but after the shift in the demography of the audience, there was a surge of programs which showed the reality of life. Larger than life emotions and problems did not suit the living room viewing as they have to be based on the reception in the living room. The program content was scrutinized for suitability for family viewership, the production budgets and plats were spruced up to suit the growing demand for variety in TV entertainment. Television did not occupy a special place in the living rooms of the families in America all a t once. The production capacities were limited and the program content was still developing, national signals were still talked about in the early decades of television. But if we analyze what caused a huge acceptance among the public that it is an essential in the living room. The magazine opinion helped in the leap of TV sets into the living room of families across America. All through the early years of television growth, it was emphasized thoroughly that television helps to improve family relationships by various sources. It was believed to bring the members of the family together. In the commercials and in the pictures in magazines, a family watching TV happily as a loving and bonding time was projected. This phenomenon was further enhanced by the baby boom and the suburbanization of American families. When families leave behind their friends and extended family, TV was positioned as an important tool to strengthen the existing family ties. Also, it
Saturday, November 16, 2019
Injuries Within Sports Games Physical Education Essay
Injuries Within Sports Games Physical Education Essay A great number of injuries occur in the context of recreational rugby games. It has been generally presumed that after a sports injury, the sports injury management programme is highly depend on compliance to sports physiotherapist recommended rehabilitation regime. Even the best treatment plan made by sports therapist specially designed for the patients could not guarantee that the patient would follow that treatment plan. Effectiveness of the specially designed treatment plan depends on the compliance of the patient. Compliance to the sports injury management program is generally less then hundred percent (Spetch and Kolt, 2001). Bassett (2003) found that 65% of athletes are either, following their rehabilitation program fully or partially and 10% of athletes did not follow their specially designed sports specific treatment plan at all. Theà England Rugby Injury Training Audit, the worlds largest continuous injury study in professional rugby union, carried out by Kemp et al (2009) reported that the sixth season of the study recorded 769 match injuries from the Guinness Premiership, EDF Energy Cup and European competitions and 258 training injuries. Simon et al (2009) pointed out that the likelihood of sustaining a match injury increased in the 2008-9 season, reversing the downward trend that had been established since the 2002-3 season. For an early return to sports, when amateur rugby players were injured, they need sports specific injury rehabilitation. Since the sports therapist is the first point of contact after the rugby player is injured on the pitch, they the sports therapist are, therefore in a sole position to analyse the players health status and to impact the sports specific injury treatment. Sports therapy is a vibrant profession that entails a sports therapist to be proficient in a number of different specialities. Although, the sports therapist must be qualified and experienced to take full charge of the physical side of the sports injury treatment, for a sports therapist simply to know how to investigate, analyse and treat a sports injury is not an adequate enough to guarantee that an amateur rugby football player is able to be rehabilitated as swiftly and effectively as possible. An imperative feature of the sports physiotherapist responsibility is to approach concerns of adherence to the sports specific injury treatment, and to communicate effectively with the player to make sure that they endeavour the essential ability to speed up their rehabilitation. The sports therapist acknowledges the significance of psychological factors in sports specific injury management adherence (Board of Certification Role Delineation Study, 2004). It is important that the therapist gets qualification and training in the psychological side of the players injury, although most accept that they did not get any sports psychological rehabilitation training (Roh Perna, 2000). Nevertheless, identifying the variables that are significant in promoting adherence and incorporating approaches to deal with these factors is a complex matters. Shuer Dietrich, (1997) argued that practitioners have investigated sports injuries from orthopaedic standpoint, but psychological treatment of amateur rugby players has not been fully addressed. Fisher, Mullins Frye (1993) argued that literature, concentrating on sports specific injury treatment, could be divided into three distinctive categories; sports therapist communication with the player, sports specific injury management features and injured amateur rugby players characteristics. Researchers have found that the players responses and awareness have been affected by their psychological attribut es. To be close to the sports therapy clinic enhance participation and a friendly atmosphere is favourable to the sports injury rehabilitation adherence (Fisher Hoisington, 1993). Prentice (1994) stated that amateur rugby players opinion of the sports therapist also influence the association between the player and the sports therapist and affect the sports injury adherence. Investigating the perspectives of this professional affiliation can improve the sports physiotherapist concepts of the amateur rugby players attitudes of, and contentment with, their sports therapist (Fisher Hoisington, 1993). Unruh (1998) pointed out that if the rugby player is satisfied with the sports physiotherapist injury rehabilitation management, then he/she would have more self assurance in the sports therapist during the sports specific injury rehabilitation management program. Fitzpatrick (1991) argued that patient contentment studies with their sports therapists supported the principal that if the rugby players are more satisfied with the sports therapist, the more they will trust him/her. Even though, the association between the sports therapist and rugby players is decisive, none of the research examined that how a sports therapist can formulate or constitute a connection to optimize their adherence. Brook et al (2005) argued that in the last decade amateur rugby players got injured at a higher rate. Since a quick return, and continuation in performance, is directly related to the results of sports injuries, how an amateur rugby football player deals with it, then further research concerning the psychological side of players is ever more significant. However, the majority of literature that has focused on injury rehabilitation has concentrated on the musculoskeletal aspects and until recently has ignored the emotional feature that could potentially play a significant role for professional athletes. With some exceptions the psychological research to date has mainly concentrated on specific factors that influence an athletes rehabilitation, such as social support (Bianco, 2001), adherence (pizzari et al, 2002), self confidence (Magyr and Dua, 2000), coping and psychological skills. Tracey (2003) has suggested that both primary and secondary appraisals fluctuate depending upon the personal and situational factors of each individual athlete. However, there are significant relationships between the primary and secondary appraisal and copying strategies. Shelly (1999, p. 306) called for further investigation into the unique perceptions and perspectives of injured athletes during rehabilitation as a means of adding depth to the research. The use of qualitative data collection on multiple occasions allows injured athletes to reflect on their experiences as they happen and to scrutinize changes over time (Podlog and Eklund, 2006). Adherence has been defined as an active, voluntary involvement of the patient in a mutually acceptable course of behaviour to produce a desired preventative or therapeutic effect. Adherence behaviour in sports injury rehabilitation may include clinic-based activities, modifying sports activities, taking medications, and completing home based activities. A number of sources, including surveys with sports medicine professionals, and research studies, suggested that low and non-adherence could be an issue in sports therapy practice. In the last decade the primary focus of the studies, carried out by researchers, to investigate the sports injury rehabilitation was to identify predictors of adherence behaviour. Brewer (2004) argued that in order to draw conclusions about the most significant issues affecting adherence to sports specific injury rehabilitation, additional research is required. Qualitative research proposes a complementary approach to quantitative studies in understanding sports specific injury rehabilitation in amateur rugby football players. Qualitative research also outlines new factors for contemplation and provides further support to previous findings. The purpose of this qualitative study was to explore amateur rugby football players experiences and perceptions of adhering to a sport injury rehabilitation program. In this study, the researcher used interviews to investigate their attitudes and contentment with their sports therapy rehabilitation. Qualitative research methodology focuses on individuals lived experiences as they are presented in thoughts, ideas, feelings, attitudes, and perceptions. Stake (1995) suggested that qualitative research gives a new approach to finding out more knowledge into the multifaceted association which took place during sports injury management. This study would explore the status of research on the sport injury rehabilitation adherence. Studies identifying variables that are correlated with adherence would be synthesized to produce a body of knowledge that will aid in the explanation of individual behavioural responses towards injury rehabilitation programs. From this qualitative investigation, using thematic coding of the interview data, categories of variables influencing adherence would emerged. In this study, the researcher would analyse acquiescence among armature rugby football players during rehabilitation. In order to improve amateur rugby football players adherence to the sports specific rehabilitation programme, strategies would be outlined for the sports physiotherapists. The predictors of sport injury rehabilitation adherence would be discussed, strategies to enhance rehabilitation adherence would be reported, and considerations for future research would be suggested. This study would provide valuable information that could be used by researchers and sports therapy practitioners to identify strategies that should enable sports therapists to structure an independent supportive atmosphere that would promote higher levels of self-regulation, enthusiasm, and strength of mind. This will help to improve adherence to the rehabilitation programmes.
Wednesday, November 13, 2019
Cinematic Techniques Essay -- essays papers
Cinematic Techniques The extraordinary film The 400 Blows (Francois Truffaut, 1959) skillfully uses cinematic devices appropriately within the context of the theme. Part of the underlying theme of this movie as explained by Truffaut himself is, ââ¬Å"... to portray a child as honestly as possible...â⬠(Writing About Film, 1982). It is the scenes in this movie that are most helpful in disclosing the overall theme of the film. Within the scenes, the camera angles in this film play an important role in accentuating the emotions behind the scene. The camera angles used in this film will be the primary focus of this paper. The high angle shots utilized in The 400 Blows are effective in helping to develop the overall feel of a scene. This movie uses the high angle shot in three different scenes to evoke three different emotions and it still works extremely well. The opening sequence uses a series of high angle shots to assist in establishing a feeling of childhood innocence and indeed, the child in this film, Antoine Dionel (Jeanne-Pierre Leaud), starts out innocent. The camera focuses of the city buildings and the sky above. As shown from a ground point of view, the buildings are larger than life and intimidating. This is how most children view the world, as being large and intimidating. Take, for example, the scenario of dropping a child off for his/her first day of school. Most of them are devastated because they have to deal with a world that is larger than the one they know, an...
Monday, November 11, 2019
Healing the World Through Literature Essay
Literature has influenced our lives in many ways. One is the way we perceive the events around us. The media have always been telling and informing the public about wars. Instead of informing us about how we can heal the world, all we hear is whose fault it was as soon as a war breaks out. The question here is: How can literature help to heal the world in terms of war and peace? This is important because there are so many wars in the world and instead of fighting we can use them to help create peace and heal the world. We will then be able look back to the past and think how we can progress for the next time. It will also help us create peace by allowing everyone to understand each other. Thomas Hardy, Anthony Hecht and Muriel Rukeyser are three authors that help show how literature can heal the world. The first poem, Thomas Hardyââ¬â¢s ââ¬Å"The Man He Killedâ⬠focuses on the senselessness and futility of war, where a man has killed another quite simply because they were fighting on opposing sides at war. It was written in the point of view of one of the soldiers who was enlisted in the infantry. In the opening stanza he states, ââ¬Å"Had he and I but met by some old ancient inn, we should have sat us down to wet right many a nipperkin! â⬠(Hardy 347) By this he means if they met outside of a pub, they would have enjoyed some drinks together, but because of the war, they are forced to shoot at one another. Then it explains how they met as soldiers in opposing sides and one had to die so they both shot each other, but the narrator shot killed the other. In the third stanza, he explains why he had to kill him. Literature could help us with war by displaying this poem. The poem shows how even when people just meet that because of a war, they are forced and required to kill another man instead of having peace. People fight in wars for all different reasons. Some people were born to join the army and be soldiers while others just join to get by in life with financial support from the army. In the lines thirteen through sixteen, towards the end of the poem the author is saying how both the men enlisted into the army because they were out of work, and they needed to sell their traps to get money, and now because of the war one of the men was killed unwontedly by another man who joined because he was out of work as well. In the second poem called ââ¬Å"More Light! More Light! â⬠by Anthony Hecht, it talks about two different stories in the poem. In the first story there is a man who was being charged for a crime he prays to his God he didnââ¬â¢t commit. He states, ââ¬Å"I implore my God to witness that I have made no crimeâ⬠(Hecht 349). He was being burned to death and one of the soldiers who was burning him because of his crime felt badly for the prisonerââ¬â¢s suffering. So he threw gun powder hoping it would catch fire and to end the prisoner of his misery but the gunpowder did not ignite, and the prisoner was burnt to death. ââ¬Å"And that was but one, and by no means one of the worst; permitted at least his pitiful dignity; and such as were by made prayers in the name of Christ, that shall judge all men, for his soulââ¬â¢s tranquilityâ⬠(Hecht 349). The second story is about three prisoners who were brought to the woods, two Jewish prisoners and one Polish prisoner. The German guards forced the Polish man to bury the Jewish men alive, but the Polish man refused to do it. So the German guards instead changed the roles, and the Polish man was shot in the stomach, buried up to his head, and was left there for three hours to bleed to death. The second story seemed to be much worse than the first because the Polish man was suffering and was only left there with his thoughts and prayers as he slowly died. ââ¬Å"No prayers or incense rose up in those hours which grew to be years, and every day came mute ghosts from the ovens, sifting through crisp air, and settled upon his eyes in a black sootâ⬠(Hecht 350). Literature help with war and peace because this poem shows the past how the Jews and Polish men and women were tortured by the Nazis and war. And this poem can teach us how even during the darkest times of war some people like the Polish did not keep his dignity. And not be forced to kill another man because war, even if the result of not listening is your own death. In the third poem ââ¬Å"Letter to the Frontâ⬠by Muriel Rukeyser, talks about being a Jew in the twentieth century. This poem explains how Jewish people should be proud of being Jewish, and they shouldnââ¬â¢t hide it. The Jewish people went through a lot with World War II, with all the deaths and sufferings, but the Jewish population shouldnââ¬â¢t try to hide what they are. ââ¬Å"Wishing to be invisible, you choose death of the spirit, the stone insanityâ⬠(Rukeyser 351). Hiding meant reducing God to nothing more than what you are. The author is saying that the Jews should be proud of who they are and what they believe in. To believe in God and pray for freedom to all people, and pray to live the impossible which can only happen with faith to their God. Not by hiding who they really are and their beliefs. Literature can help with War and peace by using this poem to show that belief in your God can help you get through any situation and not by hiding from your beliefs and who you truly are. Some people are already used to wars and violence that it doesnââ¬â¢t affect them. In order to find peace, we must first make an effort to understand all types of people. In terms of race, ethnicity, culture, values, religion, beliefs, etc. When people see life through someone elseââ¬â¢s eyes they understand what they go through. That would be the only way to avoid violence. Literature can heal the world after devastation from war. Maybe one day we wonââ¬â¢t have to worry about the war because there would be peace. Work Cited: Hardy, Thomas. ââ¬Å"The Man He Killed. â⬠Writing about the World. By Susan H. McLeod, John Jarvis, and Shelley Spear. Boston, MA: Thomson/Wadsworth, 2005. 346-48. Print. Hecht, Anthony. ââ¬Å"More Light! More Light! â⬠Writing about the World. By Susan H. McLeod, John Jarvis, and Shelley Spear. Boston, MA: Thomson/Wadsworth, 2005. 349-50. Print. Rukeyser, Muriel. ââ¬Å"Letter to the Front. â⬠Writing about the World. By Susan H. McLeod, John Jarvis, and Shelley Spear. Boston, MA: Thomson/Wadsworth, 2005. 351-52. Print.
Saturday, November 9, 2019
The San Francisco 1989 Earthquake Essays - Loma Prieta Earthquake
The San Francisco 1989 Earthquake Essays - Loma Prieta Earthquake The San Francisco 1989 Earthquake The Loma Prieta Earthquake On Tuesday October 17, 1989 at 5:04 PM the Loma Prieta earthquake struck the San Francisco, Monterey Bay, and Silicon Valley areas. Those were no the only areas affected. Many areas up to 70 and 100 miles away could feel the tremble of the quake. The epicenter of the quake was in the Santa Cruz Mountains. The quake measured a magnitude of 7.1. The initial quake lasted 15 seconds. The USGS first thought the magnitude of the quake would be about 6.9 but it increased to 7.1. The quake destroyed many buildings and freeways. A section of the San Francisco-Oakland Bay Bridge collapsed. The power was out in many places and the telephone lines were out also. This was the first time the power had been out since the 1906 earthquake. The earthquake killed 68 people and injured 3,757 people. The cost of the quake was estimated at $6 to $7 billion dollars. The quake happened during the 1989 World Series. The San Francisco Giants were playing the Oakland Athletics. The match up was called the ?Bay Bridge? World Series. The game was postponed for a month. They were playing at Candlestick Park. Airports were closed for inspection or repairs. Ceiling Tiles and broken glass were the main reason for the airports being closed. After a while the airports reopened and some local pilots helped fly emergency supplies to airports near the seriously damaged and in need areas. Roads were jammed with cars trying to get home or trying to get out of the earthquake area. The news media were desperate to get time on a satellite to broadcast their story to the rest of the world. People say that the media made the damaged areas look worse than they really were because they only focused on the bad areas and they got cities mixed up. Most people away from the center of the quake were only inconvenienced by the quake. They only had broken windows or broken pools. The insides of these people?s houses were a wreck. These people quickly recovered from the quake. The people closer to the center of the quake were not so fortunate. Some of these people lost all their belongings including their house. These people wouldn?t get things back together for months or maybe even years. Damage and loss of life were reduced because of California?s strict building codes which required buildings to be strong enough to survive even larger quakes. Having the public educated in earthquake readiness helped a lot. The people knew how to react in a quake and how to save their own life and the lives of others. The fires that broke out after the initial quake were of even worse threat. There were at least 27 fires that broke out across the city. The citizens formed a bucket brigade to help the firefighters who were without water because of water main brakes. The fires were disastrous they burned down apartment buildings, shops and even the fire chief?s house in one city. Some people went looting in the downtown areas. The District Attorney said, ?If there is anyone arrested tonight for burglary or looting, tomorrow morning we are going to go into court and demand that there is no bail. Anyone engaged in that kind of conduct can expect maximum sentences.? Some people were arrested for looting and they were severely penalized. The earthquake didn?t only cause trouble for the San Francisco Bay area. It caused a four-foot tsunami wave in Monterey Bay as well as a huge undersea landslide. The sea level in Santa Cruz dropped three feet. The wave took 20 minuets to reach Monterey. Vice President Dan Quayle and his wife flew to San Diego to see the damage. The spent four hours there and didn?t even make contact with the may who had been awake since the quake started. The mayor called the visit a ?cheap publicity stunt? Our Vice President Al Gore did the same thing when he came to Cincinnati during our flood. Mr. Gore took his shoes and socks off and put his foot in the Ohio River. What was the point of that. Mr. Quayle said this after touring the area,
Wednesday, November 6, 2019
Essentials in a Research Essays
Essentials in a Research Essays Essentials in a Research Paper Essentials in a Research Paper Research is guided by the specific research problem, question or hypothesis precisely because research originates with a question or a problem most commonly in terms of the observation of the environment though not necessarily in the sense of the ââ¬Ënatural environmentââ¬â¢. Without the perceived problem, question or hypothesis there would hardly be any reason to investigate or conduct a research in the first place. For that matter, the stimulus for the research derives from the question or problem out of observation and that, correspondingly, it should serve as the framework or the guide for the whole research. For instance, the observation that the seawater tastes salty may result to the questioning of why seawater tastes salty or to the problem of identifying what makes seawater taste salty. From then on the research is to ensue with a set of experiments and data analysis of findings, all of which are guided by the central hypothesis at hand as the core foundation of the research. A classic example which paved the way for modern scientific developments is the case of Charles Darwin. Darwin paved the way for the Theory of Evolution largely through his habit of keeping ââ¬Å"several series of notes and diaries on natural history observationsâ⬠(Porter, 1982, p. 503). If research is guided by the specific research problem, then it should also be the case that research requires the clear articulation of the goal. If the goal for the research paper is not clearly articulated, then the entire research will most likely result to the failure of arriving at the substantial conclusion given the fact that the most basic goal is not clearly defined. Given the role of the goal of the research as the main target regardless of what other things the research may arrive at in the end, it is never enough to have research goals ambiguously or vaguely articulated. Furthermore, since research is guided by the specific research problem, it should also require a specific plan for proceeding. Otherwise, the specific research problem would not serve its purpose of guiding the whole research process. A carefully laid out plan or scheme of carrying out the research paper or activity is equally important because it holds the structure of the manner or method in which the research goal is to be realized. On the other hand, the specific research plan involves the clear elaboration of the procedures in conducting the research which brings us to the next point. Research usually divides the principal problem into more manageable sub-problems. For example, in Susan Wolfââ¬â¢s (1997) article ââ¬Å"Ban Cloning? Why NBAC is Wrong,â⬠she divides the central question of her research into three sub-problems under three subheadings. This method is particularly effective because it substantiates the central question and gives more room for the scope of the research problem to be solved. And in order for the research to substantiate the central question for the research goal to be realized, the research should also accept certain critical assumptions. For instance, Archie Epps (1961) in his research the Christian doctrine of slavery accepts the critical assumption that the ââ¬Å"inability or general unwillingness to comply with and encourage the removal of segregation, discrimination and prejudiceâ⬠among others ââ¬Å"are often admittedly Christian (p. 243). By doing so, Epps was able to collect and interpret data in order to resolve the problem that initiated the research. This is another essential characteristic of research. Finally, it can be observed that research is, by its nature, cyclical or, more exactly, helical as it involves the interweaving and interlinking of the research characteristics in order to be able to support the whole research and realize the research goals and objectives. References Epps, A. C. (1961). The Christian Doctrine of Slavery: A Theological Analysis. The Journal of Negro History, 46(4), 243-249. Porter, D. M. (1982). Charles Darwins Notes on Plants of the Beagle Voyage. Taxon, 31(3), 503-506. Wolf, S. M. (1997). Ban Cloning? Why NBAC Is Wrong. The Hastings Center Report, 27(5), 12-15.
Monday, November 4, 2019
Growth Vector Analysis of Six Segments of Novartis Case Study
Growth Vector Analysis of Six Segments of Novartis - Case Study Example The term also refers to issues relating to atherosclerosis (these define diseases concerning the arterial system). Many countries around the continent have high and increasing incidents of cardiovascular diseases (Kantarjian 45). Each year, cardiovascular diseases take many American lives compared to cancer. According to Novartis, cardiovascular diseases are a significant threat and a leading cause of death to both male and female genders in most industrialized countries (Ascierto P et al 89). In the event of these statistics, besides advocating for the importance of taking preventive measures such as decreased salt intake and avoidance of all kinds of tobacco, Novartis offers wide arrays if tools for practicing physicians for the prevention and management of the disease (WHO 33). Other ways in which Novartis tries to bring down the statistics is through the administration of prescription products which include, NeoRecormon a drug used in treating patients with anemia as a result of cancer treatment and issues relating to kidney disease (Leisinger 90). Bezalip a lipid altering agent that is indispensable in prevention measures of cardiovascular diseases, and Torem a drug used in the treatment of renal failure, hypertension and congestive heart failure. In 2006, Novartisââ¬â¢ sales in drugs for the treatment of cardiovascular, related diseases accounted for 4% of the total pharmaceutical sales, a drop from 6% in 2005. The acquisition of Bezalip helped boost Novartisââ¬â¢ sales in 1998(Dahlgren G 42). According to the Novartis report in 2006, Bezalip was not a significant drug sale for the company as they sold it to another company and had to work on their other drugs that are NeoRecormon and Torem. In 2001, NeoRecormon became Novartisââ¬â¢ best sold drug totaling to $667MM. Infective and Respiratory Segment Infective and respiratory diseases describe diseases involving virus transmission through the air or bodily fluids (R. van Tulder 32). Examples are common cold, HIV/AIDS and tuberculosis among others. The influenza virus is a crucial threat to human health as concluded by Novartis research team. Transmission of the influenza flu is through sneezing or coughing. Air molecules in the atmosphere carry the virus from one person to another thereby spreading the infectious disease. As a result, Novartis has a prescription product referred to as Tami flu to aid in the prevention measures and treatment of the deadly virus (Kolk A 27). In reference to infectious diseases, various products are available to treat patients with Hepatitis C, HIV/AIDS and other infectious diseases. Products to treat HIV/AIDS include: Valcyte, Fuzeon, Viracept, and Fuzeon( Lipton J et al 40). Treatment for Hepatitis C is Pegasys. Other treatments for the infectious diseases include: Bactrium, Lariam, and Rocephin. In 2006, the sale of these drugs accounted for 21% of Novartisââ¬â¢ sales an increase of one percent compared to 2005. The most successful sales attribute to the following drugs which include: Xolair, Tami flu, Rocephin, and Pegasys. In 2004, Tami flu fetched $302mm in sales. This was a downfall of 22% from the previous year. In 2006, Tami flu sales increased due to the increasing stockpiling of drugs in readiness of pandemics. The rise resulted to 68% increase totaling to over $2.38 billion. Oncology Segment The oncology segment deals with issues relating to cancer. As a major player in Health Care, Novartis commits to providing the most
Saturday, November 2, 2019
A flying camera or a drone camera Research Paper
A flying camera or a drone camera - Research Paper Example Sergei concentrates more on the bright side of the picture in his video and can be seen proudly promoting his prototype camera. But, he does not talk some serious limitations associated with these cameras which many may be concerned with. This response paper aims to discuss the positive and negative aspects of Sergeiââ¬â¢s ted talk. It will also explore how much room there is for more improvements in the area of flying cameras with the help of research literature. The applause heard during the video when Sergei uses a small device to raise the camera high up in the air shows how taken the audience is with his demonstration and ideas. Sergei does not simply shoot arrows in thin air, but considers it critically valuable to also give a small demo to validate his talk. This action helps to acutely familiarize the audience with the product which the video is trying to promote. Another positive aspect of the video is that the presenter was lively and energetic. Words flew out of his mouth effortlessly and the points identified were briefly discussed, but in an animated fashion. There was a rigor clearly noticeable in the way information was presented to the audience. Overall, it was like going on a riveting ride with the presenter because nothing seemed boring and unimaginative. The presenter digs with acute intelligence into his subject and certain intricate features were prioritized and talked about like what innovations went into the constructio n of the device. It is implied in the video that these little drones are capable of capturing amazing footage which shows why these things are rapidly becoming ââ¬Å"todayââ¬â¢s must-have photo accessoriesâ⬠(Kolonia). Also, Sergei encourages his audience to be imaginative and creative in context of different ways in which the prototype camera can be used. Surely, there cannot be one way or one application for this device. For example, it can be used in wildlife field work.
Thursday, October 31, 2019
Maritime Budgets Struggle Article Example | Topics and Well Written Essays - 1250 words
Maritime Budgets Struggle - Article Example The implied hypothesis is that the decisions taken by the administration regarding maritime budgets in the FY 2011 budget are against the maritime industry in America and insensitive to homeland security. However, it does not throw any light on the performance of the maritime agencies in America. The hypothesis of the author appears to be skewed since it does not mention whether the budget cuts are uniform throughout various programs or specifically maritime agencies have been targeted. Also, the article glorifies the budget cuts and discounts the increase in spending on maritime agencies and programs by phrases like ââ¬Ëaging academy, and ââ¬Ëââ¬Å"difficult tradeoffsâ⬠between men and women and machineââ¬â¢ (Bondareff, 2010) The article does not answer the question regarding the impact of the budget cuts on maritime agencies and programs. The central argument of the article is that allocations in FY 2011 budget, to maritime agencies is reduced to make up for the budget deficit. Though it mentions the programs which have been denied funding in the FY 2011 budget, the article does not mention the importance/contribution of those programs to the maritime industry in particular and country in general. It does not mention the progress in the programs from the previous funding; is it the case that the programs were running excellently and now their growth would be stunted due to decreased funding or since the programs were not performing up to the expectations so the funding is decreased. The study undertaken is useful in a limited way in the sense that although it highlights the budgetary decisions of the administration regarding maritime agencies and programs, it does not throw any light on the implications of these decisions and the justifications given by administration for taking such decisions. The study appears to be a collection of
Tuesday, October 29, 2019
How Women Are Portrayed in Lynx and Cosmo Essay Example for Free
How Women Are Portrayed in Lynx and Cosmo Essay ââ¬ËMen act and women appear. Men look at women. Women watch themselves being looked atââ¬â¢ ââ¬â John Berger, ââ¬ËWays of seeingââ¬â¢. For my research investigation I intend to explore to what extent specific media products use similar representations of women to appeal to their target audiences. The examples I have chosen to focus on are the iconic, international womenââ¬â¢s fashion and lifestyle magazine ââ¬ËCosmopolitanââ¬â¢ and Lynxââ¬â¢s controversial ââ¬Ëbeach campaignââ¬â¢. I will therefore be exploring what similarities and differences they embed due to their oppositional target audiences and content. Throughout my research the main theory I will be linking to my texts is that of Laura Mulvey, her theory explores ideas of sexism and male gaze within the media industry. Hearst the publisher of Cosmopolitan describes the magazineââ¬â¢s target audience as ââ¬ËFun, Fearless Femalesââ¬â¢, the alliteration of the ââ¬ËFââ¬â¢ sound connotes a sense of attitude and fierce behaviour. Alongside the brand proposition ââ¬Ëcelebratesâ⬠¦a passion for life and inspires young women to be the best they can beââ¬â¢ consciously supporting women by portraying a sense of empowerment and ambition. In contrast, Unilever, owners of the Lynx brand state their brand prospect is that all their products are ââ¬Ëdesigned to give our customers the edge in the mating gameââ¬â¢ establishing itself as ââ¬ËUKââ¬â¢s leading male grooming brand!ââ¬â¢. Cosmopolitan are iconic for telling their audience about two main topics; lifestyle and sex. Just by looking at the magazine covers, it is clear that these two topics dominate. I researched the April 2012 cover of Cosmopolitan, it follows the generic conventions of a typical magazine format for a womenââ¬â¢s fashion and lifestyle magazine. In terms of the colour scheme the pink fonts and neutral clothing convey a sense of femininity and perhaps the everyday domestic lifestyle of women, although the lifestyle aspect of the magazine seems overpowered by the topic of sex. The cover features an attractive women ââ¬â in this case the iconic Megan Fox, posing some mildly alluring body language, showing a lot of skin, all whilst looking directly at the camera (audience) with a sexy, serious facial expression with the eyebrow promiscuously raised, and suggestive parted lips. Although the model is simply posing the latest fashion, the low cut, tightly fitting dress connotes an over sexualised view of the celebrity who is universally known as a sex symbol in the media world, taking her place in FHMââ¬â¢s sexiest women each year and continuously playing the role of the sexy female in various popular films. It is clear that Cosmopolitan use bold sexual connotations surrounding women, although argue that their intentions are in fact to empower women through their sexuality. Notice the models strong body language , the hand on hip look used alongside taglines such as ââ¬ËNaughty or nice? You decideâ⬠¦Ã¢â¬â¢, and sexual puns are even added in regarding none sexual subjects such as career advice ââ¬ËYou on topââ¬â¢, these are bold sexual connotations implying that woman should dominate to get what they want, mostly regarding the topic of sex. Perhaps fighting the controversial debate of sexism towards women in media by surprisingly embracing La ura Mulveyââ¬â¢s theory of ââ¬Ëmale gazeââ¬â¢. Cosmo put across the idea that if men find women attractive then it should accredit them by making them feel good about themselves, knowing that they look sexy and attractive. The magazine are conscious to do this in a sophisticated manor, opposed to other trashy and over sexualised magazines. Mediaknowall.com state that ââ¬ËWomenââ¬â¢s magazines have moved on and offer visions of independence and confidence as well as beauty and domestic concerns, yet women are still encouraged to look goodââ¬â¢. Body image and size have become a growing issue in society in result of magazine content. The overuse of petite, photo shopped models throughout magazines has resulted in these images becoming the dominant ideology. Over the years images printed in womenââ¬â¢s magazines have contributed to this universal feeling to look good and be a certain size. Lynx are known for their voyeuristic product advertisement, this element of the company is what attracts their buyers, yet is also their downfall. Lynx have been publicly criticized for their overuse of objectifying women, using sexualized and provocative imagery and overall blunt sexism. The BBC news state that ââ¬Ëin 2011 six of Lynxââ¬â¢s advertising campaigns were banned after mass numbers of complains were madeââ¬â¢ they added that ââ¬Ëthe 113 complaints said it was sexually suggestive and demeaning to womenââ¬â¢. I researched Lynxââ¬â¢s recent TV advertisement and accompanying print advert titled ââ¬ËThe cleaner you are, the dirtier you getââ¬â¢. Although I believe this is one of Lynxââ¬â¢s milder sexualised adverts even the title itself contains a sexual pun, suggesting the promise of sex if you shower with the product. The girl on the print advertisement is no doubt an attractive young female, fitting the iconic ââ¬Ëblonde bombshellââ¬â¢ look. The girlââ¬â¢s enticing facial expression creates the impression she is inviting the audience (male) into the shower with her. Although the girlââ¬â¢s expressions look confident, there is a contrast between this and her body language. For example the way she has to cup her bikini top to stop it from falling. This vulnerability of the woman standing half nude for a male audience completely visually depicting her as a female, making her a passive object of male visual pleasure. A comment by Jean Killbourne (a popular media activist) backs up my point by stating that ââ¬Ëwomenââ¬â¢s bodies are often dismembered into legs, breasts or thighs, reinforcing the message that women are objects rather than whole human beingsââ¬â¢. Killbourne suggests that women have become dehumanised into erotic objects for male pleasure. One element of Lynxââ¬â¢s campaigns which continues throughout is the idea of fake portrayal. In each advert the male role is played by your everyday, not overly-attractive man, contrasted with the female role being a desirable, young beauty. In an everyday world the changes of the male role attracting that type of woman are very slim. Despite this the main message that Lynx put across to their audience throughout their advertisements is that if men wear the product ââ¬â women will find them irresistible ââ¬â False portrayal. Of course this element adds humour to the advertisements, although all at the expense of objectifying women in the process and promoting the gender role of the dominant male. Bibliography Websites: www.mediaknowall.com Hearst, http.//www.hearst.co.uk/magazines/Cosmpolitan/5-about.htm Cosmopolitan, http://www.cosmopolitan.com/celebrity/exclusive/megan-fox-april-cover-cosmopolitan Exploring the media: representations and responses
Sunday, October 27, 2019
Virus-host Receptor Interactions in Biology
Virus-host Receptor Interactions in Biology Abstract Viruses are obligate intracellular parasites and, as such, must penetrate a suitable host cell in order to replicate their genomes and disseminate. Most viruses are limited to a specific set of cells or tissues in which they can successfully replicate, and this may be in one or more particular species. When viruses are able to bind a variety of cells, the pathogenesis and overall effect on the organism may differ. The main determinants of viral tropism differ between different virus families, but in order to take the first, and arguably most important step, in the infection of a host cell, the virus must attach via specific interactions between cell surface molecules and viral proteins. Enveloped viruses usually have proteins embedded in their envelope, assembled at the host cell surface prior to budding. In the case of some viruses (such as HIV-1), these may even consist of cellular proteins from the host cell itself. Non- enveloped viruses are usually internalized in some way and uncoated in an endosome in a pH-dependant manner. Many viruses require a number of cell surface receptors for cell entry, and it is this combination, added to other factors such as replication proteins, that determine whether or not a virus can penetrate and replicated within a certain cell. Introduction As obligate intracellular parasites, the life cycle of viruses depends on an intracellular replication phase and they are thus dependant on living cells. The first essential interaction a virus makes with a host cell is with a cell-surface receptor. A viral receptor may be defined as any cell surface component that mediates recognition of a cell and facilitates entry of the virus and subsequent infection. Receptors serve to ensure infection by overcoming repulsion between the virus and cell. (Baranowski, Flint, Jindrak, modern virol) Cellular receptors are generally proteins, although other types of receptor, such as carbohydrates, may be used (see table 1). These molecules are essential components of the cell or extracellular matrix and functions may include cell adhesion, signalling e.g. chemokine and growth factor receptors. (Baranowski 2003) While some viruses require only one receptor, binding to one cellular receptor alone may not be sufficient for initiation of infection for other viruses. Viruses may bind two or more receptors in sequence in order to initiate endocytosis or membrane fusion. For some viruses, the first contact with a cell is through a low-affinity interaction with a ubiquitous molecule, which allows the primary receptor-virus interaction to take place. The primary receptor is generally unique to certain cells and therefore partly defines the tropism of that particular virus, as cells are rendered susceptible to infection by a certain virus if the receptor required for attachment and entry is present. The primary attachment receptor may induce a conformational change in the viral envelope protein bound, to induce further interaction with the cell. (Modern Virology) A further interaction may then be required to initiate infection, performed by a coreceptor.The definition of the term coreceptor may sometimes be ambiguous, but generally, it is taken to be the molecule that induces fusion or penetration of a cell. This may be a further determinant of tropism, for example the interaction of HIV-1 Virus entry into a cell is the first step in the life0cycle of a virus; various mechanisms of viral cell enrty are shown in figure 1. The mechanism of entry varies between viruses, but all begin with the binding of a cellular receptor by a viral protein. Binding of a cellular receptor may induce endocytosis or formation of an endosome, the acidic environment of which induces uncoating; this may be dependent upon cellular proteins clathrin or caveolin. Enveloped viruses may require an acidic environment that will induce conformational changes in envelope proteins required to induce membrane fusion, while others, including the measles and HIV viruses, can fuse directly with the plasma membrane at neutral pH. (Baranowski) Fusion at the plasma membrane releases the nucelocapsid into the cytoplasm, where the virus can make its way to the nucleus or begin replication in the cytoplasm. The differences in these entry pathways are due to the nature of the molecular interactions between the vi ral components and target-cell receptors, for example, viruses that mimic the natural ligand of receptors for signalling molecules interefere with their signalling to promote viral entry into the cell and spread of infection. (Bomsell) Conformational changes resulting from the binding of a primary receptor that allow the binding of a fusion receptor are a common mechanism among various types of virus, including influenza and HIV type 1, examples and brief description. Similar to Influenza . Multiple receptors could be coreceptors and act together either to modulate each other or to contribute complementary functions. Alternatively, the receptors might act sequentially. Binding of the virus to the first receptor could cause changes in the virus or host that are necessary before the second receptor can bind (50). For those viruses in fluids with flow, such as blood or respiratory secretions, the initial binding must be able to effect rapid docking of the virus to its host cell. (Haywood) As previously stated, some viruses recognise more than one cellular receptor. The same receptor may also be used by more than one type of virus. (see table 1) Often, these are highly abundant in many tissues, for example, heparan sulfate can serve as a receptor for many viruses, including Human immunodefiecieny virus, Hepatitis C and Dengue Virus and as a co-receptor for Herpesviruses (excluding EBV). (ODonnel) CAR, acts as a receptor for both coxsackie and adenoviruses. (Schneider) Table 1 illustrates the diversity of cell surface molecules which viruses have adapted to recognise. Some viruses use more than one type of molecule as a primary receptor e.g. reoviruses bind to the beta-adrenergic receptor as well as NAN. (Flint) While the presence of certain receptors on host cells is vital to initiate infection, these interactions are not always sufficient to explain all aspects of cell, tissue and species tropism. (Flint)(Haywood, Schneider) Binding of a viral protein to a cell surface receptor does not necessarily mean a productive infection will follow, since a co-receptor may be absent or functional domains of the receptor may be blocked. (Baranowski) Absence of specific cytoplasmic or nuclear molecules may hinder the replication of some viruses, despite their permissivity. However, even a non-productive infection may induce pathogenic effects, for example, binding to specific receptor may induce the secretion of cytokines. (Schneider) A virus generally cannot infect a cell successfully in the absence of its specific receptor, so the distribution around the body of the receptor will act as a restriction on the range of tissues that can be infected and hence on the number of systems in the body where sig ns and symptoms of infection might be experienced. (Flint) In the true sense of the word, Tropism refers to the specific cells a particular virus is able to replicate in, although the use of receptor by a virus is increasingly a valid definition in the field of virology. Additional factors the cause viral tropism will not be considered in the context of this essay, although they may be mentioned briefly where relevant, since the focus of this review is the link between specific receptor usage and virus tropism and pathogenesis. (Kuhmann) The primary topics explored here are the virus-receptor interactions with cells that allow viruses to enter cells and initiate infection and how this relates to the tropism of the virus at a cellular and organismal level. I am to demonstrate how viral attachment and entry is often a complicated multi-step process, sometimes requiring many different cell and virus molecules. The viruses largely used to illustrate these points, Human Immunodeficiency Virus type 1 (HIV-1), Influenza A and Herpes Simplex Virus type 1 (HSV-1) are human viruses of medical significance, but the tropism of these particular viruses in other animals, along with other viruses specific to other animals will be discussed where relevant. The structure and genomic organisation of these viruses is irrelevant and is only discussed where it relates to the glycoproteins that interact with cellular receptors. Viruses of plants, fungi and bacteria are not discussed The presence on the cell surface of a protein that has been identified as the receptor for a given virus may not be sufficient for a productive viral infection, and there may be multiple mechanisms behind such restrictions: functional domains of the receptor may be blocked in some cellular context, additional proteins (or other cofactors) may be needed, or cells may exhibit impediments for completion of the infection cycle, despite an initial successful interaction with a functional receptor. HSV- Demonstrates how viruses may use a large number of viral proteins and receptors to bind and enter specific cells. (Hayashi and Yoon) and how the interactions are a complex multi-step process. Influenza multiple steps. binds many cell types Tropism is dependent on other receptors and interactions. Of the many examples, the interaction ofà the human influenza A virus hemagglutininà with N-acetylneuraminic acid, and the ensuingà conformational alterations involvedà in pH-dependent membrane fusion, are oneà of the best characterized at the structuralà and functional levels (11) (Baranowski 2001)à example of proteolytic cleavage to aid spread and pathogenesis. Conformational change required for fusion HIV A well-documented case of use of multiple receptos is that of HIV-1 viruses and related viruses. Illustrates how a virus may use multiple coreceptors to mediate entry to different types of cells and thus influence the tropism of this virus. Uses some of the same receptors as other viruses (parallels between HIV, HSV and influenza) Multi-step process The interaction of the virion with the attachment receptor leads to the first conformational changes in the envelope proteins. This step enables the interaction with co-receptors, or entry mediators and further conformational changes at the plasma membrane. In enveloped viruses (top), this may deliver the energy for the direct fusion of the viral envelope and cellular membrane. Some enveloped and non-enveloped viruses require the low pH in acidic endosomes to induce this conformational change. Enveloped viruses may require the low pH to induce membrane fusion (centre). These mechanisms lead to the release and possibly uncoating of the virus genome, and the initiation of the virus replication cycle. Role of Viral Receptor Destruction While non-enveloped viruses typically undergo relase through cytolysis. Influenza and HIV-1 Viruses also demonstrate the importance of receptor-destroying activity on the infectivity of some viruses. This is imperative for the efficient release and cell-cell spread of the virus by preventing the glycoproteins on the newly-emerged virus from binding to the host cell receptors. It is also important for preventing superinfection of cells by the same or different viruses utilising the same receptor, which may result in cell death. The efficient budding and release of Influenza A virus from the host cell relies on the removal of Sialic Acid residues by Neuraminidase. In contract, the HIV-1 virus gp120 envelope glycoprotein downregulates the CD4 receptor after infection of monocytes, by stimulating TNF-ÃŽà ± production. Other cellular mechanisms contribute to down-modulation of CD4, including the gene product Nef, which causes CD4 internalisation respectively. The precursor of gp120 and gp41, gp160, has also been found to bind CD4 intracellularly in the presence of viral protein Vpu, resulting in retention of CD4 in the Endoplasmic Rectilium. Enveloped particles leave the infected cell inconspicuouslyà by budding and secretion. Nonenveloped virusesà are usually thought to undergo release through cell lysis,à but some may escape by secretory mechanisms afterà budding into membrane bound compartments and thenà losing their membrane (Altenburg et al., 1980). Othersà may subvert cellular autophagy pathways to gain accessà to exocytic organelles (Jackson et al., 2005).à (Marsh)
Friday, October 25, 2019
Eric Eriksons Stages of Psychosocial Development Essay -- Eriksonââ¬â¢s Ei
According to Eric Erikson, there are eight different social stages a person must go through as they mature. Each stage has a positive characteristic and a negative characteristic. If positive characteristics are fulfilled then their future will look good. So to what extent can the lack of reinforcement to the positive characteristics of Eriksonââ¬â¢s psychosocial stages of development effect you? The effects can be quite horrifying. Especially if all of the stages the only characteristics fulfilled are the negative aspects. Eriksonââ¬â¢s first stage was trust verses mistrust and it occurred from zero to 18 months of age. The point of this stage is to establish trust. Erikson believed this was the most important period in a personââ¬â¢s life. Since a baby depends entirely on his/her parents, the care giving plays an important role in the shaping of this stage (Cherry, 2011). If the child successfully develops trust then the child will feel safe and secure in the world, but the lack can lead to thoughts of an inconsistent and unpredictable world (Cherry, 2011). In the business world, the lack of trust can create a whole new problem. The lack of trust can lead to the ââ¬Å"â⬠¦unseen cost in life and businessâ⬠¦Ã¢â¬ as said by Stephen Covey (2006). Lack of trust creates ââ¬Å"â⬠¦hidden agendas and a guarded communication, which slows the decision-making processâ⬠(Covey, 2006). When there isnââ¬â¢t trust in a situation, it hinders productivity, innovation (Covey, 2006). The second stage is autonomy verses shame and doubt. This occurs from about 18 months of age to 3 years old. The basic virtue of this stage is will; can they do things on their own or do they require the help of others? Erikson believed that children around this age wanted to develop a greater sense... ...r past with little or no regrets and will be satisfied overall. If a person is unsuccessful in this phase they will feel that they wasted their life and they will only think of regrets. They will feel despair (Cherry, 2011). Eriksonââ¬â¢s stages of psychosocial development were complex, but simple. It is something everyone will go through and experiences will always be different. The lack of reinforcement to the positive aspects of his stages can lead to quite a disaster. Surprisingly, previous stages are highly influential to the proceeding stage. The lack of reinforcement to the positive aspects of his psychosocial stages can have a very devastating effect on a person. This is because the effects built up rather than taking the place of one another. The effects are quite horrifying, but with the right environment, experiences and beliefs, everything can go well.
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